Abstract
Syntheses of the potent angiotensin converting enzyme inhibitor 1-(carboxymethyl)-3-(mercaptomethyl)-2,3,4,5-tetrahydro-1H-1- benzazep in -2-one (4a) and the corresponding eight-membered ring analogue (4b) are described. The influence of ring size on the inhibitory potencies of these substances is discussed.
MeSH terms
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Angiotensin-Converting Enzyme Inhibitors*
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Animals
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Azocines / chemical synthesis*
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Azocines / pharmacology
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Benzazepines / chemical synthesis*
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Benzazepines / pharmacology
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Captopril / analogs & derivatives*
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Lung / enzymology
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Male
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Proline / analogs & derivatives*
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Rabbits
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Azocines
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Benzazepines
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3-(mercaptomethyl-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid), dicyclohexylamine salt
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3-(mercaptomethyl)-3,4,5,6-tetrahydro-2-oxo-1H-1-benzazocine-1-acetic acid
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Proline
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Captopril